Onconext is the new Genoma Group division entirely committed to oncology. The division is formed by a multidisciplinary team of professionals specialised in molecular biology and genetics applied to the study of solid tumors.
Onconext tests are planned to detect somatic and germinal mutations from blood or tissue biopsy sample.
The introduction of the study for preventive purposes of germinal mutations, related to inherited solid tumors, has allowed over the years to improve, not only prognosis of potential pathologies through personalised supervision programs, but also the management of patients in case of need fortargeted pharmacological treatments.
The consolidated use of molecular biology in oncology in order to identify the presence of somatic mutations allowed, besides, to centralize the human relationship with the patient, and to meet person’s needs more and more, through the development and the employment of “smart medicines”.
Since 1953, with Watson and Crick discovery of DNA double helix, it begins molecular biology and genetics era.
The medicine immediately enjoys the benefits deriving from the discoveries of these new scientific areas, and in the ’70s the first “proto-oncogene” was discovered, is a gene that codify for a protein that regulatescell proliferation.
Between the 80s and the 90s, with the advent of PCR and of the “Human Genoma Project”, “tumor suppressor genes” are detected, and they, unlike proto-oncogenes, limit cell proliferation;besides,thefirst “targeted” medicines able to distinguish and hit only diseased tissuessparing healthy oneshave been developed.
The publication of the complete map of human genome represents the real turning point of oncology.
Molecular targeted therapies are considered the new frontier in the treatment of tumor. Compared to traditional chemotherapies, limited by the inability to act in a selective way damaging indiscriminately all high reproductive cells, targeted therapies can damage only tumor cells by recognising special receptors on their membranes.
Even if new therapies act in a targeted way, they are responsible fora good number of side effects, although different from classic chemotherapies, and today clinical research is almost exclusively oriented in this direction.
The future in oncology, like any other science, is unpredictable but the past and present successes are able to create a scenario for better future perspectives for patients, and for high-risk individuals, compared to a few decades ago.
Comforting results emerge from recent discoveries about immunology applied in oncology field, of “cell” therapies employing stem cells, nanotechnologies and epigenetic drugs.
Although it is believed the right directionhas been taken, it is still early for considering cancer a closed chapter, and a long journey of research and successes is still necessary.
Cancer mortality continues to decrease.
Decreasing between -7% and -10%
(Standardized mortality rate on the European population by geographical area and sex)
Data source Airtum 2016.
Test for the study, by blood sample, of germinal mutations predisposing to the development of inherited tumors.
Test for the study, by blood sample, of somatic mutations for early diagnosis or molecular characterization of a tumor.
Everything you need for the collection and the shipment is entirely supplied
Sending of the material and picking up
of the sample included
Possibility of pre and post genetic counselling with medical geneticist
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Genoma Group srl
Genoma Group is the result of an innovative project and of a new way of interpreting laboratory activity: the creation of a new highly specialised diagnostic centre, through which provide a qualified support in Genetics and Molecular Biology field.